U.S. Patent No. 5,879,703

Dermazone sunscreens have undergone
the following toxicological and sensitivity tests:

Primary Skin Irritation – testing conducted for a 24-hour period and evaluates the acute irritation of material applied topically onto the skin. The primary indicator of irritancy in these tests is the degree of redness or erythema.

Photoallergenic Potential – testing evaluates the photoallergenic potential of test materials following UV-A irradiation on human subjects. The degree of erythema is evaluated 24 hours and 48 hours after application of the test material following the UV-A irradiation and occlusion for twenty-four hours prior to the first evaluation of the test site. This evaluates the likelihood of allergic reactions to test materials applied topically onto intact human skin after exposure to UV-A radiation.

Phototoxic Potential – testing evaluates the potential of test material to elicit topical toxic effects after application of test materials onto human subjects. The degree of erythema is evaluated immediately following at twenty-four and forty-eight hours and one week after a 24 hour test period in which the test material was placed onto the skin, the skin was UV-A irradiated and the occluded under a dressing material for 24 hours.

Sun Protection Factor – testing evaluates the ability of test materials to prevent redness on human skin after a topical application of test material followed by UV radiation of one minimal dose. Subjects are evaluated 24 hours after irradiation.

Waterproof Determination – testing evaluates the ability of test materials to remain on the skin and resist removal during water immersion. This test is done in conjunction with SPF testing on human subjects. After topical application of test materials, and allowing 30 minutes for the skin to dry, the test site is immersed in water for 20 minutes and rested out of water for 20 minutes. The test site is subjected to four cycles of immersion and drying prior to UV irradiation. The test site is then evaluated 24 hours later to determine the degree of erythema and hence the SPF number.

Extended Waterproof – testing is used to evaluate the ability of test materials to remain substantially on the skin after 8 hours of repeated exposure to water. This testing is conducted on human subjects and is identical to the waterproof testing with the exception that the test site undergoes repeated cycles of water immersion and drying for full 8 hours prior to UV irradiation.

These studies have shown that our sunscreen products are non-toxic, non-irritating, and maintain their waterproof properties for up to eight hours. Neither the SPF 15 nor the SPF 30 has shown any comedogenicity. All the ingredients in the sunscreens are all very well known with a high safety profile.
Most sunscreens start with a high level of protection, which diminishes over time; their properties held in the skin by oils, polymers or waxes, which can clog. Dermazone sunscreens, because of the penetration of the actives into the stratum via the liposome, do not contain these pore-clogging materials. In addition, Dermazone sunscreens maintain their SPF factor throughout the eight-hour period. They also provide an optimal moisturizing effect to the skin because of their water content, which is why we refer to them as moisturizing sunscreens.

DERMAZONE’S sunscreens have been the sunscreen of choice for the Olympic Swiss Ski Team for 5 years.
DERMAZONE’S sunscreens have been the sunscreen of choice for Physicians around the world for over 12 years.